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KMID : 1123920060200051261
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 5 p.1261 ~ p.1270
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Experiment Report about the Effect on the Anti-cancer of Herbal-acupuncture with Evodiae Fructus Infusion Solution
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Cha Kwan-Bae
Yoo Ho-Ryong
Oh Young-Seon
Seol In-Chan
Cho Hyun-Kyoung
Kim Yoon-Sik
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Abstract
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This study was done to investigate the effect of anti-cancer, anti-metastasis and immune response improvement of herbal-acupuncture with Evodiae Fructus herbal infusion solution(EF-HAS). To study the effects of anti-cancer, anti-metastasis and immune response improvement of EF-HAS, we injected EF-HAS into Chung-wan(CV12) of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma. Then, we have examined the effect on the increasing of spleen cells, the effect on the number of CD25/CD4, CD8/CD3e, CD69/B220, NK1.1/CD3e cells in mice’s PBMCs, the effect on the pulmonary colony number, and the effect on median survival time(MST) and increase of life span(ILS) of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma. The following results were obtained; in the experiment groups treated with EF-HAS, the spleen cell proliferation in C57BL/6 mice, the percentage of CD25/CD4, CD8/CD3e, CD69/B220, NK1.1/CD3e cells in C57BL/6 mice’s PBMCs, and MST and ILS of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma were significantly increased compared with that of the control group. And in the experiment groups treated with EF-HAS, the pulmonary colony number of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma was decreased significantly compared with that of the control group. These results support a role for EF-HAS might De usefully applied in treatment of cancer.
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KEYWORD
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Evodiae Fructus(EF), Herbal-acupuncture, Chung-wan(CV12), Anti-cancer, Immune response improvement
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